Get Involved. Donate Today. Create Event or Memorial Page.
Other Giving Opportunities. Research Partners.
Late-Onset Mental Illness Unravels a Family's Life | Brain & Behavior Research Foundation
Team Up for Research! Sponsorship Opportunities. Healthy Minds TV. Ask the Expert. Grant FAQs. Outstanding Achievement Prizes. Lieber Prize for Schizophrenia Research. Maltz Prize for Schizophrenia Research.
- Earplugs for Motorcyclists.
- Facts about Bipolar Disorder - ADAMHSCC.
- La belleza entra por la boca (EPUBS) (Spanish Edition);
- Jesus Our Portion: A devotional for those dealing with PTSD or dissociative disorders from childhood abuse.
- Project MUSE - Bipolar Disorder in Later Life?
- Dancing Leaves.
Colvin Prize for Mood Disorders Research. The Pardes Humanitarian Prize. Productive Lives Awards. About Us.
Who We Are. Media Center.
Stay in the Know
Multimedia Library. Connect Ask the Expert Join Us.
Bipolar Disorder in Late Life (BPD)
Download PDF Download. Under a Creative Commons license.
Firstly, it allows us to study the precursors and prodromes of the disorder; as well as the lifetime risk and comorbidities. But most importantly, it enables us to plan primary and secondary prevention, and early interventions.
This may not be as simple as it sounds. It could mean one of several things, including the age when the first signs of a disorder appear e. There are in fact several, heterogeneous criteria to define the age of onset. Currently, there are no widely agreed definitions of the onset and initial management of bipolar disorder, and the effect of treatment delay on the outcome of bipolar disorder is unknown.
Prof de Girolamo and colleagues undertook a meta-analysis to look into the interval between the onset and the initial management of bipolar disorder. Twenty-seven studies were identified from 5, articles using pre-defined selection criteria, and were included in the quantitative analysis. While there was very high between-sample heterogeneity, it was found that the pooled interval between the onset of bipolar disorder and initial management was almost six years! Using sensitivity analysis of the onset definitions, it was shown that the interval for first symptoms, first episode and illness onset were 5.
Prof de Girolamo proposed that the marked variation between the studies was partly explained by the way in which onset was defined, how the chronology of onset was assessed, the average age of onset, the proportion of patients with bipolar disorder I and when the study was published. Regardless of the heterogeneity observed, the clinical implications are clear: even in research centers, there is an unacceptably long interval between the emergence of symptoms and the identification and treatment of bipolar disorder.
This study identifies an opportunity for intervention in the early stages of illness, which may in turn postpone or prevent the progression of bipolar disorder. Prof Kupka emphasized the point made by Prof de Girolamo, that there is huge variation in the definition of the age of onset of bipolar disorder. This is partly because a diagnosis of unipolar depression may precede the first manic episode by years - even decades - at which time a diagnosis of bipolar disorder would be considered.
Late-Onset Mental Illness Unravels a Family's Life
Data from 7 studies, including 2, patients, highlight that a large proportion of patients with bipolar disorder are diagnosed between 15 and 19 years of age. Of the patients included in a study by the SFBN, the mean age was Prof Kupka pointed out a patient who first suffered from depression as a teenager, but only reported symptoms of mania when he was over 65 years of age!
Prof Kupka proposed that genetic loading may play a greater role in early onset bipolar disorder, compared with late onset. In addition, data from the SFBN showed that physical and sexual abuse in childhood play a role in earlier age of onset of bipolar disorder. Verbal abuse in childhood was also associated with an earlier onset and more difficult course of illness. Prof Kupka concluded that SFBN-data reveal that an earlier age of onset is associated with a poorer long-term outcome - more depression, mood instability and rapid cycling- as well as a longer delay to first treatment.
Related Bipolar Disorder in Later Life
Copyright 2019 - All Right Reserved